MovDisordV3, Main, Exploration, bibRecord, 002E75

ELAVL4, PARK10, and the Celts

Identifieur interne : 002E75 ( Main/Exploration ); précédent : 002E74; suivant : 002E76

ELAVL4, PARK10, and the Celts

Auteurs : Kristoffer Haugarvoll [États-Unis, Norvège] ; Mathias Toft [États-Unis, Norvège] ; Owen A. Ross [États-Unis] ; Jeremy T. Stone [États-Unis] ; Michael G. Heckman [États-Unis] ; Linda R. White [Norvège] ; Timothy Lynch [Irlande (pays)] ; John Mark Gibson [Irlande (pays)] ; Zbigniew K. Wszolek [États-Unis] ; Ryan J. Uitti [États-Unis] ; Jan O. Aasly [Norvège] ; Matthew J. Farrer [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-03-15.

RBID : ISTEX:854CA06A79DBF113B64DFF23D15A88F6ADA1C79D

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Système nerveux pathologie.
Wicri :
- geographic : Norvège.

English descriptors

KwdEn :
- Adult, Age Factors, Aged, Aged, 80 and over, Alleles, ELAVL4, Female, Genetic Linkage (genetics), Genetic Markers, Genetic Predisposition to Disease, Hu Paraneoplastic Encephalomyelitis Antigens (genetics), Humans, Male, Middle Aged, Nervous system diseases, Norway (ethnology), PARK10, Parkinson Disease (ethnology), Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Point Mutation (genetics), Protein-Serine-Threonine Kinases (genetics), Ubiquitin-Protein Ligases (genetics), United States, genetics.
MESH :
- chemical , genetics : Hu Paraneoplastic Encephalomyelitis Antigens, Protein-Serine-Threonine Kinases, Ubiquitin-Protein Ligases.
- chemical : Genetic Markers.
- geographic , ethnology : Norway.
- ethnology : Parkinson Disease.
- genetics : Genetic Linkage, Parkinson Disease, Point Mutation.
- Adult, Age Factors, Aged, Aged, 80 and over, Alleles, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, United States.

Abstract

Genetic variability in ELAVL4 located in the PARK10 locus was recently associated with age‐at‐onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. We examined five markers spanning ELAVL4 in Norwegian, United States, and Irish PD case–control samples. No association was found between the examined markers and AAO or PD in Norwegian or US samples. However, ELAVL4 markers (rs967582 and rs3902720) were significantly associated with susceptibility to PD in our Irish series. Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic‐founder effect. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/854CA06A79DBF113B64DFF23D15A88F6ADA1C79D/fulltext/pdf

DOI: 10.1002/mds.21336

Affiliations:

Le document en format XML

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<author><name sortKey="Toft, Mathias" sort="Toft, Mathias" uniqKey="Toft M" first="Mathias" last="Toft">Mathias Toft</name>
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<author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name>
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<author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name>
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<author><name sortKey="Gibson, John Mark" sort="Gibson, John Mark" uniqKey="Gibson J" first="John Mark" last="Gibson">John Mark Gibson</name>
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<author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
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<author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name>
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<author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name>
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<affiliation wicri:level="3"><country xml:lang="fr">Norvège</country>
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<author><name sortKey="White, Linda R" sort="White, Linda R" uniqKey="White L" first="Linda R." last="White">Linda R. White</name>
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<author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name>
<affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Department of Neurology, Mater Misericordiae Hospital, Dublin and the Conway Institute, University College Dublin</wicri:regionArea>
<wicri:noRegion>University College Dublin</wicri:noRegion>
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<author><name sortKey="Gibson, John Mark" sort="Gibson, John Mark" uniqKey="Gibson J" first="John Mark" last="Gibson">John Mark Gibson</name>
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<author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Alleles</term>
<term>ELAVL4</term>
<term>Female</term>
<term>Genetic Linkage (genetics)</term>
<term>Genetic Markers</term>
<term>Genetic Predisposition to Disease</term>
<term>Hu Paraneoplastic Encephalomyelitis Antigens (genetics)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Norway (ethnology)</term>
<term>PARK10</term>
<term>Parkinson Disease (ethnology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Point Mutation (genetics)</term>
<term>Protein-Serine-Threonine Kinases (genetics)</term>
<term>Ubiquitin-Protein Ligases (genetics)</term>
<term>United States</term>
<term>genetics</term>
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<term>Protein-Serine-Threonine Kinases</term>
<term>Ubiquitin-Protein Ligases</term>
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</keywords>
<keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Linkage</term>
<term>Parkinson Disease</term>
<term>Point Mutation</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Alleles</term>
<term>Female</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>United States</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Système nerveux pathologie</term>
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<front><div type="abstract" xml:lang="en">Genetic variability in ELAVL4 located in the PARK10 locus was recently associated with age‐at‐onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. We examined five markers spanning ELAVL4 in Norwegian, United States, and Irish PD case–control samples. No association was found between the examined markers and AAO or PD in Norwegian or US samples. However, ELAVL4 markers (rs967582 and rs3902720) were significantly associated with susceptibility to PD in our Irish series. Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic‐founder effect. © 2007 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Irlande (pays)</li>
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<li>Trøndelag</li>
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<name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name>
<name sortKey="Stone, Jeremy T" sort="Stone, Jeremy T" uniqKey="Stone J" first="Jeremy T." last="Stone">Jeremy T. Stone</name>
<name sortKey="Toft, Mathias" sort="Toft, Mathias" uniqKey="Toft M" first="Mathias" last="Toft">Mathias Toft</name>
<name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name>
<name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name>
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<country name="Norvège"><region name="Trøndelag"><name sortKey="Haugarvoll, Kristoffer" sort="Haugarvoll, Kristoffer" uniqKey="Haugarvoll K" first="Kristoffer" last="Haugarvoll">Kristoffer Haugarvoll</name>
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<name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name>
<name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name>
<name sortKey="Toft, Mathias" sort="Toft, Mathias" uniqKey="Toft M" first="Mathias" last="Toft">Mathias Toft</name>
<name sortKey="White, Linda R" sort="White, Linda R" uniqKey="White L" first="Linda R." last="White">Linda R. White</name>
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<country name="Irlande (pays)"><noRegion><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name>
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<name sortKey="Gibson, John Mark" sort="Gibson, John Mark" uniqKey="Gibson J" first="John Mark" last="Gibson">John Mark Gibson</name>
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Movement Disorders (revue)

ELAVL4, PARK10, and the Celts

ELAVL4, PARK10, and the Celts

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.